IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology?

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IFN-g in human Chagas disease: protection or pathology?

An apparently paradoxical role for IFN-γ in human Chagas’ disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infe...

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Severe destruction of intrinsic cardiac nerves has been reported in experimental acute Chagas myocarditis, followed by extensive regeneration during the chronic phase of the infection. To further study this subject, the sympathetic and para-sympathetic intracardiac nerves of mice infected with a virulent Trypanosoma cruzi strain were analyzed, during acute and chronic infection, by means of his...

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Evolution and pathology in chagas disease--a review.

Trypanosoma cruzi acute infections often go unperceived, but one third of chronically infected individuals die of Chagas disease, showing diverse manifestations affecting the heart, intestines, and nervous systems. A common denominator of pathology in Chagas disease is the minimal rejection unit, whereby parasite-free target host cells are destroyed by immune system mononuclear effectors cells ...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 1998

ISSN: 0100-879X

DOI: 10.1590/s0100-879x1998000100017